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Although effects of low concentrations of
2024-10-26
Although effects of low concentrations of agonist were not as thoroughly documented for heteromeric receptors such as the major Tie2 kinase inhibitor α4β2 nAChR, a similar mechanism of action was described to explain the potentiation of these receptors with low concentrations of acetylcholine-estera
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The hippocampus is the primary brain structure involved in
2024-10-26
The hippocampus is the primary brain structure involved in learning and memory. The role of hippocampal synaptic plasticity in neurological processes in cognition and depression has been extensively demonstrated. Synaptophysin is a critical substance in synaptogenesis, which is necessary for learnin
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br Experimental procedure br Introduction Migraine is a
2024-10-26
Experimental procedure Introduction Migraine is a debilitating neurovascular disorder characterized by recurring unilateral pulsating headaches of moderate to severe intensity, associated with nausea, photophobia and/or phonophobia, lasting from 4 to 72 h (Headache Classification Committee of
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A positive correlation between nasopharyngeal CCL and CCL co
2024-10-25
A positive correlation between nasopharyngeal CCL3 and CCL5 [16] concentrations and illness severity was shown in evaluating patients with RSV bronchiolitis [17]. CCL5 and CCL3 are important for monocyte and lymphocyte recruitment to the lung during RSV infection [7], [16], [18]. Despite the signifi
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Previous studies have demonstrated ATR inhibition is effecti
2024-10-25
Previous studies have demonstrated ATR inhibition is effective for treating cancers combining with chemotherapies in lung adenocarcinoma, gastric cancer, HER2 positive breast cancer and chronic lymphocytic leukemia Pyronaridine Tetraphosphate mg to enhance chemotherapy sensitivity [[16], [17], [18]
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Etoposide receptor Recent studies have demonstrated signific
2024-10-25
Recent studies have demonstrated significant cross-talk between XRCC1 (a key player in Etoposide receptor excision repair (BER) and single strand break repair) and DDR [30], [31], [32]. ATM and DNA-PKcs are known to be involved in the phosphorylation of XRCC1 to promote BER [30], [31]. We have rece
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Angiogenesis is a process of formation
2024-10-25
Angiogenesis is a process of formation of new vessels from arterial vascularization created by endothelial cells. It is essential for the continuous growth of the tumor because it supplies the tumor with nutrients and oxygen, and eliminates cellular waste, which can be toxic to cancer cells [8]. Inf
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Inhibition of autophagy has been shown to alleviate
2024-10-25
Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention
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LAP locations in the parasite tissues
2024-10-25
LAP locations in the parasite tissues would provide clues for the potential physiological roles of it inside the parasite body. To date, tissue localization of LAPs has been carried out in many helminth parasites; however, information regarding LAPs in tapeworm is scarce. It was shown that LAPs were
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In large biopsies series from ALK NSCLC treated patients the
2024-10-25
In large biopsies series from ALK+ NSCLC treated patients, the number of detected mutations increased after second generation ALKi (Gainor et al., 2016) and in one study were present in 56% of the entire cohort (Shaw et al., 2013b). For example, the rate of G1202R mutations increases from 2% in post
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In this study for the first instant we report
2024-10-25
In this study, for the first instant we report the characterization, production and in silico structural analysis of BADH1 gene in B. haloduranss SMBPL06 isolated from the salt pan. Moreover, the sequence analysis of betaine aldehyde dehydrogenase from B. haloduranss SMBPL06 displayed several base s
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Chlorothiazide The anorexic effect observed when AR
2024-10-24
The anorexic effect observed when AR231630 is infused into the VTA could be the result of the DA release inhibition, as previously described [11]. However, there is also a hedonic aspect in feeding that possibly involves dopaminergic mechanisms of reward. Helm et al. showed a functional link between
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NLX a k a F or befiradol
2024-10-24
NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in how to make dilutions to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Addition
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ATP citrate lyase ACLY is
2024-10-24
ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl-CoA from citrate [15]. Acetyl-CoA is the building block for the biosynthesis of fatty acids and cholesterol, and also serves as a substrate of the acetylation reaction of various molecules, including histones and
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br Breast cancer The interactions
2024-10-24
Breast cancer The interactions between 15-LOX and COX enzymes also affect the outcome of breast cancer. Indomethacin, a COX-1 and COX-2 inhibitor, decreased the growth of human breast cancer (BC) cells in nude mice, as well as slowed the rate of lung metastasis formation [41]. The levels of 12-H
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