• Although CP has been an

  2023-12-22

  

  Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular BINA by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of autopha

• Imatinib is a well known

  2023-12-22

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing crotaline mg (K562 ce

• Cancer cells manifest characteristic abnormal growth propert

  2023-12-22

  

  Cancer Fructose synthesis manifest characteristic abnormal growth properties accompanying clonal evolution of cells displaying progressively increasing genomic instability capable of invasion and metastasis to distant organ sites. With the emerging knowledge about the role of known oncogene and tumo

• br Oxidative microbe killing and V ATPase Oxidative killing

  2023-12-22

  

  Oxidative microbe killing and V-ATPase Oxidative killing of phagocytosed microorganisms is predominately achieved through the uptake of large quantities of molecular oxygen by the infected cell and the activity particularly of the NADPH oxidase complex on phagosomes (Savina et al., 2006) and the

• ZCL278 receptor In addition to connecting high ARG levels wi

  2023-12-22

  

  In addition to connecting high ARG1 levels with DNMT3A/TET2 mutations in MDS/CMML patient biopsies, we also wanted to address the cell type demonstrating elevated ARG1. Following our mouse work, we hypothesized that overexpression of this protein would be found in myelomonocytic ZCL278 receptor inc

• ARG I is one of the most important

  2023-12-22

  

  ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino SGC707 receptor and nucleotide metabolism [18]. ARG I deficiency leads to hyperargininemia, characterized by progres

• br Acknowledgments and Disclosures br Introduction Over

  2023-12-21

  

  Acknowledgments and Disclosures Introduction Over the last decade, the most visible strategy for the treatment of Alzheimer's disease (AD) has been amyloid β peptide (Aβ) immunotherapy (reviewed in [1]). Although the first efforts with Aβ immunotherapy failed to complete clinical trials [1],

• Cell Counting Kit-8 br Material and methods br Results br

  2023-12-21

  

  Material and methods Results Discussion RSV is a major cause of lower respiratory tract infections in infancy and early childhood. Several observations suggest that immunological mechanisms may be the key to understand the severity of RSV bronchiolitis in infancy. Several laboratories have

• To validate the identified phosphorylation sites in the mous

  2023-12-21

  

  To validate the identified phosphorylation sites in the mouse heart, we analyzed HEK 293T glut 1 transfected with Adrb1 based on the hypothesis that protein residues phosphorylated both in vivo and in vitro are more likely to be physiologically relevant. All of the phosphorylation sites identified

• br Material and methods br Results br Discussion

  2023-12-21

  

  Material and methods Results Discussion To develop a novel regenerative and/or neuroprotective therapy for optic neuropathy, including glaucoma, numerous studies have tested new candidates favorable to RGC survival and axon regeneration. Among the many candidate drugs, AdoR modulators are o

• ADORs accomplish a variety of physiological effects

  2023-12-21

  

  ADORs accomplish a variety of physiological effects in different tissues. In neurons, ADORs regulate the release of neurotransmitters such as dopamine and glutamate (Ferré et al., 1992; Fredholm and Dunwiddie, 1988; Ginsborg and Hirst, 1972; Gonçalves et al., 2015; Quarta et al., 2004; Stella et al.

• The gene SRD A encodes the

  2023-12-21

  

  The gene SRD5A2 encodes the 5-α-reductase enzyme, which converts testosterone into dihydrotestosterone. Although dihydrotestosterone levels are considerably lower than testosterone, dihydrotestosterone has a five-fold stronger binding capacity to the androgen receptor and, thereby, a considerably mo

• Because serum ATX activity and plasma

  2023-12-21

  

  Because serum ATX activity and ionophore LPA are well correlated with liver fibrosis stage histologically, both of these parameters merit consideration as novel markers of fibrosis. However, serum ATX activity may be a more useful test from a clinical laboratory perspective. First, LPA can increase

• br Conclusion br Acknowledgments and

  2023-12-20

  

  Conclusion Acknowledgments and disclosure We thank Ms. Crystal Wylie for her help in the preparation of the manuscript. The development of the database upon which analyses of this study were dependent was supported by PO1 DC 00161 from the National Institute on Deafness and Other Communicatio

• While there is much in vivo

  2023-12-20

  

  While there is much in vivo work on prion-like Aβ, it has not been shown that one can induce inclusions of Aβ in cultured cells as has been shown for tau and α-synuclein. One reason is practical; Aβ is a low molecular weight metabolite cleaved from within the larger amyloid precursor protein (APP) a

16508 records 231/1101 page Previous Next First page 上5页 231232233234235 下5页 Last page